منابع مشابه
MicroRNA signature of cis-platin resistant vs. cis-platin sensitive ovarian cancer cell lines
BACKGROUND Ovarian cancer is the leading cause of death from gynecologic cancer in women worldwide. According to the National Cancer Institute, ovarian cancer has the highest mortality rate among all the reproductive cancers in women. Advanced stage diagnosis and chemo/radio-resistance is a major obstacle in treating advanced ovarian cancer. The most commonly employed chemotherapeutic drug for ...
متن کاملThermodynamic Parameters of Cis-Platin and Trans-Platin Complexes with Guanine in Water, A DFT Study
The binding energy and Thermodynamic Parameters of cis- Platinum Di Ammino Chlorine (cis-[Pt(NH3)2Cl]+) and trans- Platinum Di Ammino Chlorine (trans- [Pt(NH3)2Cl]+) complexes withGuanine has been studied by density functional theory (DFT) calculations in water. The bindingenergies (Ebin) of cis- and trans-[Pt(NH3)2ClG]+ are calculated to be 79.38 kcal/mol and 74.98kcal/mol, respectively. The b...
متن کاملSynthesen ortho-nitrosubstituierter Bis(phenyl)platin(II)-Verbindungen
ds-Bis(phenyl)bis(triphenylphosphan)platin(II)Verbindungen vom Typ cis-1 hatten ergeben, daß diese regiospezifische [1 — 8], thermisch symmetrieer laubte [9] pericyclische Reaktion am Übergangsme tall [1 —8] sich immer dann durch besonders niedrige Aktivierungs-Enthalpien auszeichnet, wenn der eine Phenylring durch Substituenten X substituiert ist, die die Elektronendichte auf dem unmittelbar...
متن کاملMultifunctional magnetic calcium phosphate nanoparticles for targeted platin delivery.
Magnetic mesoporous amorphous calcium phosphate nanoparticles with a size of 62 nm and abundant -COOH groups on the surface have been prepared by a simple method. The particles show excellent aqueous dispersion stability in physiological pH without any deterioration in hydrodynamic size and zetapotential. By virtue of the carboxylate groups on the surface, the platinum pharmacophore cis-diaquad...
متن کاملCis-platin responsive sequences in the human c-myc promoter.
We have transfected recombinant plasmids carrying 5' c-myc sequences linked to the reporter gene chloramphenicol acetyl-transferase (cat) and to the selectable marker aminoglycoside phosphotransferase (aph) into rat fibroblasts and obtained stable transfectants. The response to cis-platin of these cell lines was studied. At 5 X 10(-5) M concentration cis-platin stimulates cat gene expression 9 ...
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ژورنال
عنوان ژورنال: Zeitschrift f�r Analytische Chemie
سال: 1917
ISSN: 1618-2642,1618-2650
DOI: 10.1007/bf01470293